Introduction | Analytic solution of PKPD model, multiple study arms | ODE solution of PK model, multiple dosing | ODE solution of TMDD model with 2 outputs, Multiple arms, different dose routes, different number of sample times per arm | Model with continuous covariates | Model with discrete covariates | Model with Inter-Occasion Variability (IOV) | Full omega matrix | Include a prior FIM, compute power to identify a parameter | Design evaluation including uncertainty in the model parameters (robust design) | Design evaluation for a subset of model parameters of interest (Ds optimality) | Shrinkage | Further examples

Define a model | Create a PopED database | Design simulation | Design evaluation | Evaluate alternative design | Comparison of designs | Design optimization | Examine efficiency of sampling windows | Optimize over a discrete design space | Optimize 'Other' design variables | Cost function to optimize dose

Introduction | Estimated NCA metrics | Estimation method | Output | Tabular output | ncaOutput.tsv | ObsStat.tsv | SimStat.tsv | ncaSimData.tsv | ncaSimEst.tsv | Graphical output | [Individual level] Concentration vs. time profile | [Population level] Histogram of the selected NCA metrics estimated from the observed data | [Population level] Histogram of the simulated population means of the NCA metrics | [Individual level] Deviation of the simulated NCA metrics from the observed value | [Individual level] Distribution of the simulated NCA metrics for the outliers} | [Population level] Histogram of the NPDE values of the NCA metrics within a given population group | [Population level] Forest plot for the NPDE type analysis | [Individual level] NPDE values of the NCA metrics for each individual